SPINDLE CELL CARCINOMA FREE

The squamous cell component forms a minor portion of the tumor mass which may be represented by dysplasia, carcinoma in situ or invasive carci¬noma. Histopathologically, SCSCC show the presence of two distinct components: a squamous cell carcinoma and sarcomatoid spindle cell component. Dysphonia was the main symptom in our cases. Hoarseness is the most frequent symptom dysphonia, dysphagia, or airway obstruction and cough were usually observed. This tumor typically presents as a polypoid mass, usually involving the glottis (70% of cases) which is similar to our report. In our series, all patients were male and heavy smokers the median age was 60,6 year. Men are much more affected, especially in the seventh decade of life. Laryngeal SCSCC is strongly associated with tobacco and alcohol abuse, prior radiation to the larynx has been noted in a few studies. Given the controversy surrounding its histogenesis, this tumor was termed as sarcomatoid carcinoma, pleomorphic carcinoma, pseudocarcinoma, carcinosarcoma. It is a bimorphic tumor made up of a squamous cell carcinoma component and a spindle cell proliferation. SCSCC is a rare and highly malignant variant of SCC.

SPINDLE CELL CARCINOMA FREE

The patient remains free of disease at 3-years follow-up. All margins were negative and lymph nodes metastases were absent. A final diagnosis of spindle cell squamous carcinoma was made considering the presence of in situ SCC. Histological analysis of surgical specimen showed sarcomatous proliferation the spindle cells are arranged in fascicular architecture with moderate to highly nuclear atypia and many mitoses. Macroscopically, it was an exophytic tumor of the right vocal cord with 2, 2× 2, 5 ×1, 8 cm in size reaching the anterior commissure and the subglottis. A total laryngectomy with bilateral neck dissection was performed. Immunohistochemical analysis was positive for vimentin, SMA, PS100, focally for EMA and negative for keratin and P63 (Figure 2). Pathology revealed in situ squamous cell carcinoma with sarcomatous invasive component (Figure 1). Laryngoscopy showed an exophytic tumor involving the right vocal cord. Their clinical characteristics, treatment, pathological features and outcomes were retrospectively reviewed.Ī 50-year-old-man, with a 20 pack-year smoking history, presented dysphonia that dates back 3 months.

Three cases of laryngeal SCSCC were identified at our institution during a period of 12 years from 2009 to 2020. This uncommon tumor still poses a challenge in diagnosis, prognosis and therapeutic approach. This tumor has now been proved to be monoclonal, evolving from conventional squamous carcinoma with sarcomatoid dedifferentiation. SCSCC was considered as a biphasic tumor with both carcinomatous and sarcomatous components. Considerable controversy has long surrounded this tumor due to its heterogeneous terminology, rarity and disputed histogenesis. It represents 2 to 3% of all laryngeal tumors and 1% of head and neck SCSCC. Spindle cell squamous cell carcinoma (SCSCC) of the larynx is a rare variant of squamous cell carcinoma (SCC). Spindle cell squamous cell carcinoma, larynx, sarcomatous transformation, osteosarcoma, immunohistochemistry All patients were well controlled after treatment and there was no recurrence during the following up. Immunohistochemical analysis performed in one patient was positive for vimentin, SMA, PS100, focally for EMA and negative for keratin and P63.One case presented lymph nodes metastases and an adjuvant radiotherapy was preconised for this patient. One case showed basaloid squamous cell carcinoma with sarcomatous transformation and osteosarcoma. Histological examination confirmed the diagnostic of SCSCC. The patient underwent laryngectomy with bilateral neck dissection. The tumor involves the vocal cord in all cases. The patients were smoker men aged 50, 66 and 66 years old respectively. In the present report, three cases of laryngeal SCSCC were inves¬tigated their clinical, pathological findings, treatment and outcomes are described. This tumor still poses diagnostic and therapeutic challenges.

It remains uncommon in the larynx and represents only 1 % of SCSCC of the head and neck. Spindle cell squamous cell carcinoma (SCSCC) is a rare malignant tumor, which involves both squamous cell carcinoma and sarcomatoid proliferation. Spindle Cell Squamous Cell Carcinoma of The Larynx: A Report of Three Cases A B S T R A C T

Spindle cell carcinoma